Mono gameplay:

Hit colors. Dodge greys.

Puzzle League gameplay:

Your goal is to make color clusters with three or more blocks of the same color touching. After a short time, clustered colors will collect for points.

Binaural

Never hit a grey to get a stealth bonus.
There's two kinds of color blocks. Mixed matches get a minor bonus.
Making matches increases chain bonus. Hitting greys decreases it. Overflowing or not hitting anything for a while resets the bonus.
Fill the grid before the big Power Pellet spheres to turn blocks into Power Blocks for longer time.
Greys stay in the grid for a few moments, and may prevent matches being collected. They stay longer the higher they are.
Bonus points are awarded for largest match during the song.